ETS-1 Oncogenic Activity Mediated by Transforming Growth Factor α
نویسندگان
چکیده
منابع مشابه
Epidermal growth factor-mediated activation of the ETS domain transcription factor Elk-1 requires nuclear calcium.
Cytosolic and nuclear Ca(2+) have been shown to differentially regulate transcription. However, the impact of spatially distinct Ca(2+) signals on mitogen-activated protein kinase-mediated gene expression remains unknown. Here we investigated the role of nuclear and cytosolic Ca(2+) signals in epidermal growth factor (EGF)-induced transactivation of the ternary complex factor Elk-1 using a GAL4...
متن کاملRegulation of the megakaryocytic glycoprotein IX promoter by the oncogenic Ets transcription factor Fli-1.
Glycoprotein (GP) IX is a subunit of the von Willebrand receptor, GPIb-V-IX, which mediates adhesion of platelets to the subendothelium of damaged blood vessels. Previous characterization of the GPIX promoter identified a functional Ets site that, when disrupted, reduced promoter activity. However, the Ets protein(s) that regulated GPIX promoter expression was unknown. In this study, transient ...
متن کاملAntitumor Activity of a Transforming Growth Factor
TGF-a-PE40 is a chimeric protein composed of transforming growth factor a (TGF-a) linked to a modified Pseudomonas toxin from which the cell recognition domain has been deleted (PE40). TGF-a-PE40 has been shown to have cytotoxic effects on human cancer cell lines that express the epidermal growth factor (EGF) receptor on their surface, and when given ¡.p., it prolongs the survival of nude mice...
متن کاملTransforming growth factor- pathway activity in glioblastoma
Transforming growth factor (TGF)-� is a central molecule maintaining the malignant phenotype of glioblastoma. Anti-TGF-� strategies are currently being explored in early clinical trials. Yet, there is little contemporary data on the differential expression of TGF-� isoforms at the mRNA and protein level or TGF-�/Smad pathway activity in glioblastomas in vivo.Here we studied 64 newly diagnosed a...
متن کاملTransforming growth factor-beta 1-mediated collagen gel contraction by cardiac fibroblasts.
OBJECTIVE Myofibroblasts and transforming growth factor-beta(1) (TGF-beta(1)) are key elements of cardiac tissue fibrosis development. The aim of this study was to determine whether the ability of TGF-beta(1) to affect the contractile activity of cardiac fibroblasts depends on their differentiation into myofibroblasts. METHODS Cardiac fibroblasts (from male adult Wistar rats) from passage two...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cancer Research
سال: 2010
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-09-2090